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Expected Research Outputs of WG3

1. To identify at least the 2 most important co-morbidities to consider when designing preclinical and clinical cardioprotection studies (factors include age, male sex, diabetes, hypertension, hypercholesterolemia).

2. To identify at least the 2 most important co-medications to consider when designing preclinical and clinical cardioprotection studies (co-medications include anti-platelet agents, statins, anesthetics, nitrates).

Working Group 4: Consortium

Many of the cardioprotective therapies that have failed in the clinical setting did not show consistent and robust cardioprotection in the experimental setting. This can be attributed to methodological limitations of the pre-clinical studies including lack of randomization, non-blinded treatment allocation, non-blinded data analysis, lack of standardized animal models and IRI protocols, and the lack of rigor in statistical methods. Therefore, more rigorous testing of novel cardioprotective therapies in the experimental setting is required to ensure that only the most promising therapies are investigated in the clinical arena. As such in this COST Action proposal, we will put in place a Consortium for (a) multi-center experimental testing of new cardioprotective therapies in clinically relevant small/large animal and human models of acute IRI; and (b) testing of new cardioprotective therapies in proof-of-concept clinical studies in patients subjected to acute IRI including STEMI and CABG patients.

The Consortium, which will be termed the European Cardioprotection Consortium (ECC), will allow multi-site testing of novel cardioprotective therapies in clinically relevant experimental small and large animal models and is, in part, modeled on the National Institute of Health-sponsored CAESAR collaborative network (Consortium for Preclinical Assessment of Cardioprotective Therapies) in the United States( Free shipping 2017 Spring new high heels fashion sweet elegant fine with high heels suede shallow mouth pointed Office Lady shoes buy cheap factory outlet EFugp32
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; Jones et al., 2015 ). The ECC will improve upon the NIH CAESAR collaborative network by (a) building on the infrastructure and knowledge obtained from the 3 WGs, in identifying novel cardioprotective targets and innovative strategies; and (b) undertaking proof-of-concept clinical studies in STEMI and CABG patients.

Expected Research Outputs of WG4

1. To put in place a network of research centers across Europe that will constitute the ECC for multi-center randomized controlled pre-clinical and clinical testing of novel cardioprotective therapies.

2. To standardize acute myocardial IRI protocols across the consortium and select which small animal (mouse, rat, rabbit) and large animal (pig, dog) AMI/HF models to include in the ECC.

3. To identify at least 4 novel cardioprotective therapies from WG 1, 2, 3 and key confounders highlighted in WG3 for testing in our ECC.

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22. Design your book cover to look good small.

Design your book cover to look good small.

Traditional book publishers design -- or at least they used to design -- a book cover to make a book stand out in a bookstore and evoke whatever sentiment it was supposed to evoke. Well, with Amazon becoming a dominant bookseller, your book has to stand out as a thumbnail image online because that's how most people are going to come across it. If you're primarily selling through Amazon, think small and work your way up.

23. If you're selling online, make the most out of your Amazon page.

If you're selling online, make the most out of your Amazon page.

I'm a little bit surprised by how neglectful some self-published authors are when it comes to their Amazon product pages. I've talked to self-published authors who spend a few thousand dollars on a publicist and their Amazon product page looks woeful -- and they've barely even looked at it. I ask, "Where are people going to buy your book?" They don't seem to realize how important Amazon is. True, some people market through a Web site or buy Google keywords to drive traffic there. But you need to have your Amazon page look as good as possible and take advantage of the tools Amazon has to help you surface your book ("Tags," Listmania, reader reviews, etc.). It may not have a major impact, but it's better than doing nothing. You should check out Amazon's Author Central to get some helpful tips.

One tip: Make sure your book is put into five browsing categories (it's only allowed five). It helps to categorize your book to readers and also will make your book look better if it's a bestseller in those categories. Way back when I self-published, no one at BookSurge suggested this to me; I had to figure it out on my own. (Again, they don't care, you have to make them care).

24. Pricing is a serious challenge.

Pricing is a serious challenge.

The biggest problem with going the POD route is that it costs more to produce one-offs of your book than it does to produce thousands. I remember that you could buy my book -- it was a paperback -- from BookSurge for $5.70. It was about 370 pages. Now, if I went ahead and had the thing printed up directly through an off-set printer -- and ordered a few thousand of them -- I could probably cut the cost of the book in half, and maybe even a little more. But I'd have to pay the upfront fee to buy the books and then I'd have to figure out a way to sell them (this is how vanity presses used to work -- you had to agree to buy a few thousand books).

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» Duty to Accommodate

Manitoba Human Rights Code – Duty to Accommodate

At Brandon University, we recognize our responsibility to address and remove barriers that staff and faculty may encounter based on the protected characteristics identified in the Manitoba Human Rights Code. By doing so, we are meeting our duty to accommodate.

The Manitoba Human Rights Code (“The Code”) prohibits an employer from discriminating against a person based on various characteristics including physical or mental disability, family status, religious belief and gender identity. For a full list of the protected characteristics, please visit the Manitoba Human Rights Commission website . Discriminating also means a failure to provide a reasonable accommodation for the needs of a person when they are based on the protected characteristics.* As the employer, it is our obligation to ‘level the playing field’ through reasonable accommodations so that all employees have equal access to opportunities at work. The Manitoba Human Rights Commission has developed a helpful guideline regarding Reasonable Accommodation in the Workplace .

No two accommodations look the same. Accommodations can take many forms; from adjusting work start times to ergonomic workstation adjustments.Should these types of accommodations be medically required, Human Resources will request supporting medical documentation to accompany the buy cheap new arrival SIGERSON MORRISON Sandals buy cheap best sale HQsIs5vm

It is important to remember that an accommodation request is based on a n eed not a w ant . While an employee may view their want as a need, they do not get to choose their accommodation. As the employer, we require supporting documentation from practitioners or physiciansand wewill often request subsequent information to assist us in determining what is practicably reasonable.

To help better understand workplace accommodations, take the time to review the following policy, procedure and supporting forms:

In cases where an employee is set to return to work after an illness or injury, there are often restrictions or limitationsas part of theirreturn to work plan. Because we are required to ensure the employee does notexceed their limitations and possibly risk further injury or setbacks to their recovery, Human Resources will ask for medical documentation outlining any restrictions prior to the employee’s return to work.

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